About Painful Lumbosacral Radiculopathy

Painful lumbosacral radiculopathy (PLSR), commonly known as sciatica, is a type of nerve damage that occurs when nerves in the lower back cannot signal properly. This dysfunction in the nerves is caused by damage or disease, such as disc herniation or narrowing of the spine. Nerve damage like PLSR is a major cause of disability worldwide, and it often negatively affects sleep, mood, and day-to-day life.

Symptoms of PLSR can include:

  • Pain in the lower back and leg
  • Tingling
  • Numbness
  • Muscle weaknessFootnote1

Treatment for PLSR usually centers around relieving pain and managing symptoms. Clinical research studies and volunteer participants are vital to the development of potential future treatment options that may provide an alternative for individuals with PLSR. If you’re interested in the NAVIGATOR-2 Study, we invite you to see if you may qualify.


  1. my.clevelandclinic.org/health/diseases/22564-radiculopathy
See if you may qualify